Category: Pharmaceutical

Trifluoromethanesulfonic anhydride

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Description

Triflation of Alcohols and Phenols: Converts hydroxyl groups into triflates, which are excellent leaving groups for further substitution or cross-coupling reactions.

Carbonyl Activation: Transforms ketones into enol triflates and amides into reactive imidoyl triflates, enabling functional group transformations.
Dehydration Agent: Used to remove water in the synthesis of nitriles, isonitriles, and ketenes.
Catalyst/Promoter: Functions as a strong Lewis acid to facilitate Friedel-Crafts acylations, cyclizations, and polymerization reactions.
Pharmaceutical/Agrochemical Synthesis: Essential for synthesizing active ingredients requiring precise, high-yield functional group transformations.
Electrochemical Application: Used as an electrolyte component due to high stability.

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